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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They can be uncommon In this particular malignancy when compared with other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A also are mutated in a small proportion of clients. Of